MUC5A

Clone JAC5 validated for IHC detection of MUC5AC in routine-fixed FFPE tissue sections.
Fig.01 Intense MUC5AC immunostaining in stomach cancer (diffuse type).
Fig.12 Malignant mixed Müllerian tumor of the uterus with strong focal MUC5AC positivity in epithelial tumor cells.
Fig.11 Positive MUC5AC staining in a low grade adenoma of the colon.
Fig.10 Patchy MUC5AC immunostaining in a cholangiocellular carcinoma of the liver.
Fig.09 Cholangiocellular carcinoma of the liver with focal MUC5AC positivity.
Fig.08 Endometroid cancer of the endometrium with strong strong diffuse MUC5AC expression.
Fig.07 Focal MUC5AC positivity in endometroid cancer of the endometrium.
Fig.06 Strong diffuse MUC5AC staining in a mucinous carcinoma of the ovary.
Fig.05 Mucinous carcinoma of the ovary with strong MUC5AC staining in a fraction of cells (mosaic pattern).
Fig.04 Adenocarcinoma of the ampulla Vaterii (pancreas) with strong focal expression of MUC5AC.
Fig.03 Strong patchy MUC5AC staining in an adenocarcinoma of the ampulla Vaterii (pancreas).
Fig.02 Diffuse type stomach cancer with strong MUC5AC positivity.

Clone JAC5 has been validated specifically for routine immunohistochemical (IHC) detection of MUC5AC in formalin-fixed paraffin-embedded tissue specimen.

Mucin 5AC glycoprotein (MUC5AC) is secretory-type mucin with 641kDa. Mucins are high molecular weight glycoproteins produced by epithelial cells and can be divided into two families; secretory mucins and membrane bound mucins. MUC5AC is highly expressed in surface mucosal cells of respiratory tract and stomach epithelia as a mucus-forming secreted, but not in normal colon cells. A number of carcinomas overexpress MUC5AC. MUC5AC expression is indicated in carcinomas wherein the type is defined as diffuse and infiltrative, and in carcinomas located mainly in the antrum. Moreover MUC5AC expression is correlated with colorectal signet-ring cell carcinoma: Overexpression of MUC5AC relates to the carcinogenesis, malignant potential, progression, and clinical behaviors. MUC5AC expression is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2.

Anti-MUC5AC may be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas. MUC5AC antibodies may also be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary.

MUC5A Antibody Productdetails

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