CD112R antibody for multiplex IHC
Anti-PVRIG/CD112R clone R12 has been developed for detection of CD112R in routine formalin-fixed paraffin-embedded tissue specimen (IHC FFPE) to be used in bright field immunohistochemistry and moreover for multicolor immunofluorescence (fluorescence multiplex IHC). Anti-PVRIG/CD112R clone R12 has been validated for sensitivity and specificity on large quantities of normal and tumor tissues.
Clone R12 displays no background in non lymphoid cells and in epithelial cells. Based on the high specificity combined with an inherent high signal to noise ratio clone R12 is ideally suited for multiplexed immunohistochemistry studies of CD112R in human tissue specimen.
CD112R is preferentially expressed on T-cells and inhibits T-cell receptor mediated signals. Blockade of the CD112R-CD112 interaction enhances T cell response.