FOXP3 antibody for multiplex IHC

Anti-FOXP3 antibody clone FX3 validated for fluorescence multiplex immunohistochemistry
FOXP3
FOXP3
Multicolor Immunofluorescence of FOXP3 (red) and CD112R (green), magnification 40x, normal tonsil
FOXP3 antibody
FOXP3 antibody
FOXP3 positive TILs in a high grade serous Ovarian carcinoma
Focal accumulation of FOXP3 positive TILs in a solid cancer
FOXP3 antibody
FOXP3 antibody
Higher magnification of the same cancer as in Figure 6. Note the optimal signal to noise ratio of immunostaining.
FOXP3 antibody
FOXP3 antibody
FOXP3

Clone FX3 has been developed and validated for fluorescence multiplex IHC studies of FOXP3 expression in human tissues.

FOXP3 (Forkhead box protein P3) is mainly expressed in Regulatory T (Treg) cells, a subset of CD4+ T-cells, that play a suppressive role in the immune system. Treg cells ensure immune homeostasis through their ability to suppress the activation and function of leukocytes. FOXP3 has emerged as a prominent target for the development of new immunotherapies for cancer and autoimmune diseases.

The transcription factor FOXP3 is important for the development and inhibitory function of regulatory T-cells (Treg) and acts either as a transcriptional repressor or as a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. FOXP3 coordinates the suppressive activity of Treg cells by activation of different genes, including CTLA4 and TNFRSF18, paralleled by repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG) .

FOXP3 Antibody Productdetails

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