MUC5AC

328,00 plus VAT

#DIA-MUC-OD
Anti-MUC5A (Hu) from Mouse (clone JAC5) – 100 µl
Category:

Description

Cat.No.DIA-MUC-OD
SpecificityMUC5AC
Species ReactivityHuman
Host SpeciesMouse
IsotypeIgG1
CloneJAC5
Application
Immunohistochemistry (IHC),
Formalin-fixed Paraffin-embedded sections (FFPE)
Western Blot
Conjugationunconjugated
DilutionIHC 1:100-1:200
Format
Liquid
Antibody purified (from culture supernatant)
Quantity100µl
Control tissueStomach, Endometrium
PresentationTris pH 7.3-7.7, with 1% BSA, <0.1% NaN3
Intended UseResearch Use Only
 Manufacturer / BrandONCOdianova
MUC5AC IHC-Gallery
IHC-figures and legends on MUC5AC detection in different tumors.

Reactivity

Clone JAC5 has been validated specifically for routine immunohistochemical (IHC) detection of MUC5AC in formalin-fixed paraffin-embedded tissue specimen.

Mucin 5AC glycoprotein (MUC5AC) is secretory-type mucin with 641kDa. Mucins are high molecular weight glycoproteins produced by epithelial cells and can be divided into two families; secretory mucins and membrane bound mucins. MUC5AC is highly expressed in surface mucosal cells of respiratory tract and stomach epithelia as a mucus-forming secreted, but not in normal colon cells. A number of carcinomas overexpress MUC5AC. MUC5AC expression is indicated in carcinomas wherein the type is defined as diffuse and infiltrative, and in carcinomas located mainly in the antrum. Moreover MUC5AC expression is correlated with colorectal signet-ring cell carcinoma: Overexpression of MUC5AC relates to the carcinogenesis, malignant potential, progression, and clinical behaviors. MUC5AC expression is present in primary ovarian mucinous cancer but usually absent in colorectal adenocarcinoma, thus showing an expression pattern opposite to MUC2.

Anti-MUC5AC may be useful for identification of intestinal metaplasia as well as in the identification of pancreatic carcinoma and pre-cancerous changes vs. normal pancreas. MUC5AC antibodies may also be useful for differential identification of primary mucinous ovarian tumors from colon adenocarcinoma metastatic to the ovary.

References

References

  1. Mino-Kenudson M, et al. Mucin expression in reactive gastropathy: an immunohistochemical analysis. Arch Pathol Lab Med. (2007) 131:86-90.
  2. O’Connell FP, et al. Utility of immunohistochemistry in distinguishing primary adenocarcinomas from metastatic breast carcinomas in the gastrointestinal tract. Arch Pathol Lab Med. (2005) 129:338-347.
  3. Rakha EA et al. Expression of mucins (MUC1, MUC2, MUC3, MUC4, MUC5AC and MUC6) and their prognostic significance in human breast cancer. Mod Pathol. (2005) 18(10):1295-1304.
  4. Sean KL et al. Differential Expression of MUC1, MUC2, and MUC5AC in Carcinomas of Various Sites. An Immunohistochemical Study. Am J Clin Pathol (2004)122:61-69.
  5. Baldus SE et al. Correlation of MUC5AC immunoreactivity with histopathological subtypes and prognosis of gastric carcinoma. Ann Surg Oncol. (2002) 9:887-893.
  6. Kuan, S. et al. Differential Expression of Mucin Genes in Mammary and Extramammary Paget’s Disease. Am J Surg Pathol. (2001) 25:1469-1477.

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